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Thursday, October 31, 2019
Tuesday, October 29, 2019
Reverse Aging
Aging Is Reversible
At Least in Human Cells and Live Mice.
New research suggests it is possible to slow or even reverse aging, at least in mice, by undoing changes in gene activity—the same kinds of changes that are caused by decades of life in humans.
By tweaking genes that turn adult cells back into embryoniclike ones, researchers at the Salk Institute for Biological Studies reversed the aging of mouse and human cells in vitro, extended the life of a mouse with an accelerated-aging condition and successfully promoted recovery from an injury in a middle-aged mouse, according to a study published Thursday in Cell.
The study adds weight to the scientific argument that aging is largely a process of so-called epigenetic changes, alterations that make genes more active or less so. Over the course of life cell-activity regulators get added to or removed from genes. In humans those changes can be caused by smoking, pollution or other environmental factors—which dial the genes’ activities up or down. As these changes accumulate, our muscles weaken, our minds slow down and we become more vulnerable to diseases.
The new study suggests the possibility of reversing at least some of these changes, a process researchers think they may eventually get to work in living humans. “Aging is something plastic that we can manipulate,” says Juan Carlos Izpisua Belmonte, the study’s senior author and an expert in gene expression at Salk. In their study Belmonte and his colleagues rejuvenated cells by turning on, for a short period of time, four genes that have the capacity to convert adult cells back into an embryoniclike state.
In living mice they activated the four genes (known as “Yamanaka factors,” for researcher Shinya Yamanaka, the Nobelist who discovered their combined potential in 2006). This approach rejuvenated damaged muscles and the pancreas in a middle-aged mouse, and extended by 30 percent the life span of a mouse with a genetic mutation responsible for Hutchinson–Gilford progeria syndrome, which causes rapid aging in children.
Because the Yamanaka factors reverse changes made to gene regulators, some scientists see the study as further evidence that aging is driven by epigenetic changes. “I do think that epigenetic reprogramming is the ultimate way to reverse aging,” says David Sinclair, a Harvard University geneticist and anti-aging researcher who was not involved in the study but is doing similar work. “My lab has a lot of evidence that the primary driver of what we call the hallmarks of aging is the epigenetic change.” Sinclair says his lab is preparing a paper explaining what causes these changes as we age.
The Salk study was conducted on middle-aged mice. But in theory, reprogramming epigenetics should work on mice and people at any age, says first author Alejandro Ocampo, adding that even cells from human centenarians could eventually be rejuvenated. He and Belmonte say they think they can improve the efficiency and results of the technique with more research—and that they can undo the epigenetic changes responsible for aging by using easier-to-handle chemicals instead of the Yamanaka factors, hopefully moving toward the possibility of treatment for people.
Matt Kaeberlein, a molecular biologist at the University of Washington who studies aging but was not part of the work, says other researchers have found that the Yamanaka factors can rejuvenate cells—so in some ways this study is not surprising. But Kaeberlein says no one else had yet shown that the factors can treat age-related diseases in an animal by making the same changes. “That’s the wow factor,” he explains.
Kaeberlein says the study suggests it may be possible not just to slow aging but to actually reverse it. “That’s really exciting—that means that even in elderly people it may be possible to restore youthful function,” he says. Plus, it is easier to imagine a treatment that makes changes to the epigenome than to consider going into every cell and changing its genes. He also notes that the results of the new study are very similar to those seen when senescent cells—those that have lost function due to aging—are removed from an organism. It is not yet clear, he says, whether “this is another way to shut down or maybe reprogram senescent cells.”
Monday, October 28, 2019
Get Shredded
WORLD’S MOST SHREDDED GUY And WORKOUT!!!
This is a story about Helmut Strebl. If you’ve not heard about this man before, then let me remind you that he’s the same ripped guy whose pictures are seen doing round on the internet, accompanied with captions like ‘world’s most ripped man’ and Mr. Shredder. A look at his pictures and you can’t contest the names given to this man. His extremely low body fat percentage is a testament of what can be achieved with decades of hard work and dedication coupled with good genetics. He has competed and modelled for almost two decades now and is well known for his motivational speeches apart from a godly ripped physique. Here’s his story.
Helmut is not a usual bodybuilder who gets into shape before an event. He maintains the same level of conditioning throughout the year. He weighs 205 to 215 at a height of 6’3′ all year round with a body fat percentage of around 4 to 5 percent. He is a bodybuilder and a model by profession who has competed in many events and even featured in a music video with Madonna.
He first competed at the Mr. World 1996, where he ranked 11th. The same year he went on to become Mr. Austria 1996. Thereafter he appeared for many natural bodybuilding competitions like Muscle Mania and European Natural Bodybuilding Championships. He has even won these titles more than half a dozen of times. His latest trophy was that of the Miami Pro World Championship, 2014. In the same competition, he was also crowned best muscle model over 40.
Sunday, October 27, 2019
To Much Salt
Lowering salt intake could stave off dementia
A high-salt diet may negatively affect cognitive function.
A high-salt diet may negatively affect cognitive function by causing a deficiency of nitric oxide, which is vital for maintaining vascular health in the brain, according to a new study in mice from Weill Cornell Medicine researchers.
When nitric oxide levels are too low, chemical changes to the protein tau occur in the brain, contributing to dementia.
The investigators concluded that lowering salt intake and maintaining healthy blood vessels in the brain may “stave off” dementia. Accumulation of tau deposits has been implicated in the development of Alzheimer’s disease in humans.
“Our study proposes a new mechanism by which salt mediates cognitive impairment and also provides further evidence of a link between dietary habits and cognitive function,” said lead author Giuseppe Faraco, an assistant professor of research in neuroscience in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine.
The study builds upon research published in 2018 that found that a high-salt diet caused dementia in mice. The rodents became unable to complete daily living tasks such as building their nests and had problems passing memory tests. The research team determined that the high-salt diet was causing cells in the small intestine to release the molecule interleukin-17 (IL-17), which promotes inflammation as part of the body’s immune response.
IL-17 enters the bloodstream and prevents the cells in the walls of blood vessels feeding the brain from producing the compound nitric oxide. This compound works by relaxing and widening the blood vessels, allowing blood to flow. Conversely, a shortage of nitric oxide can restrict blood flow.
In their new study, the investigators found that decreased nitric oxide production in blood vessels also affects the stability of tau proteins in neurons. “Tau becoming unstable and coming off the cytoskeleton causes trouble,” said Costantino Iadecola, senior author of the study. He added that tau is not supposed to be free in the cell. Once tau detaches from the cytoskeleton, the protein can accumulate in the brain, causing cognitive problems. The researchers determined that healthy levels of nitric oxide keep tau in check. “It puts the brakes on activity caused by a series of enzymes that leads to tau disease pathology,” he said.
Overall, the study highlights how vascular health is important to the brain. “As we demonstrated, there’s more than one way that the blood vessels keep the brain healthy,” Iadecola said.
Saturday, October 26, 2019
Treat Scares
How Do Scars Form?
Scars form when the dermis (deep, thick layer of skin) is damaged. The body forms new collagen fibers (a naturally occurring protein in the body) to mend the damage, resulting in a scar. The new scar tissue will have a different texture and quality than the surrounding tissue. Scars form after a wound is completely healed.
There are different kinds of scars. Most scars are flat and pale. However, in cases when the body produces too much collagen, scars can be raised. Raised scars are called hypertrophic scars or keloid scars. Both of these kinds of scars are more common in younger and dark-skinned people.
Some scars can have a sunken or pitted appearance. This kind of scarring occurs when underlying structures supporting the skin (for example, fat or muscle) are lost. Some surgical scars have this appearance, as do some scars from acne.
Scars also can appear as stretched skin. Such scars result when the skin stretches rapidly (for example, as in growth spurts or during pregnancy). In addition, this type of scar can occur when the skin is under tension (near a joint, for example) during the healing process.
How Can Scars Be Treated?
Although scars cannot be completely removed, their appearance can be improved to some extent. Methods for improving the appearance of scars include:
- Topical treatments, such as vitamin E, cocoa butter cream, and several commercial skin care products sold over the counter may be somewhat effective in helping to heal scars.
- Surgery. Although it will not remove a scar, surgery can be used to alter a scar’s shape or make it less noticeable. Surgery is not recommended in cases of hypertrophic or keloid scarring (raised scars) because there is a risk of recurring scars as well as more severe scarring that results from the treatment.
- Steroid injections. A course of steroid injections into a scar may help flatten it. Injections may help to soften the appearance of keloid or hypertrophic scars.
- Radiotherapy. Low-dose, superficial radiotherapy is used to prevent recurrence of severe keloid and hypertrophic scarring. This treatment is used only in extreme cases because of potential long-term side effects.
- Dermabrasion. This treatment involves the removal of the surface of the skin with special equipment. Dermabrasion is useful to blend in the irregularities of a scar whether it is raised or depressed.
- Microdermabrasion is a much less invasive form of dermabrasion but is minimally useful for very superficial scars.
- Laser resurfacing . This procedure, similar to dermabrasion, removes the surface layers of the skin using different types of lasers. Newer types of lasers may achieve more subtle results by working on the collagen in the dermis without removing the upper layers of skin. This advancement results in little down time as opposed to traditional laser resurfacing and dermabrasion, which requires a longer recovery.
- Filler injections. These treatments can be used to raise sunken scars to the level of surrounding skin. The effects of these injections are only temporary, however, and the procedures may need to be regularly repeated. Newer forms of injectable fillers are now on the market and may be an option for some people.
- Microneedling. Many small puncture holes are made into the superficial skin to stimulate collagen production and even introduce collagen stimulators or other products to try to reduce the appearance of scars.
Thursday, October 24, 2019
Feel Younger
Look and Feel Younger
Berberine
Berberine Information
Berberine is a chemical found in several plants including European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree turmeric.
Berberine is most commonly taken by mouth for diabetes, high levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia), and high blood pressure. It is also applied to the skin to treat burns and canker sores, but there is no good scientific evidence to support these uses.
How does it work?
Berberine might cause stronger heartbeats. This might help people with certain heart conditions. Berberine might also help regulate how the body uses sugar in the blood. This might help people with diabetes. It also might also be able to kill bacteria and reduce swelling.
https://stimulife.blog/look-and-feel-younger-1-2-3/
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